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Caroline J. Zeiss, D.V.M., Ph.D.
Associate Professor of Comparative Medicine
Associate Professor of Ophthalmology & Visual Science
Section of Comparative Medicine
126 LSOG
Yale School of Medicine
New Haven, Connecticut 06520
Phone: (203) 737-4303
Fax: (203) 785-7499
caroline.zeiss@yale.edu
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Research Interests:
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Ocular pathology with emphasis on photoreceptor disorders
Neuroanatomy of age-related gait disorders
Signal transduction events during neuronal death
Comparative pathology with emphasis on murine neuroanatomy
Phenotying genetically altered rodents |
Selected Publications:
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Zeiss CJ, Acland GA, Aguirre GD.1999. Light microscopic and ultrastructural characterization of retinal pathology in a canine model of X-linked retinitis pigmentosa. Invest Ophthalmol Vis Sci. 40(13):3 292-304.
Zeiss CJ, Ray K, Acland GM and Aguirre GD. 2000. Mapping of X-linked Progressive Retinal Atrophy (XLPRA), the Canine Homolog of Retinitis Pigmentosa 3 (RP3), and Characterization of RPGR Splice Variants. Hum Mol Genet. 1;9(4):531-7.
Qi Zhang, Gregory M. Acland, Barbara Zangerl, Jennifer L. Johnson, Zuohua Mao, Caroline J. Zeiss, Elaine A. Ostrander, and Gustavo D. Aguirre. 2001. Fine Mapping of Canine XLPRA Establishes Homology of the Human and Canine RP3 Intervals. Invest Ophthalmol Vis Sci.42: 2466-2471.
Johnson, Dennis R., Finch, Rick A., Lin, Z. Ping, Zeiss, Caroline J., Sartorelli, Alan C. 2001.The Pharmacological Phenotype of Combined Multidrug-Resistance mdr1a/1b- and mrp1-deficient Mice. Cancer Res 61: 1469-1476.
Zeiss CJ, Johnson EM, Dubielzig RR. 2003.Feline intraocular tumors may arise from transformation of lens epithelium. Vet Pathol. 40(4):355-62.
Zeiss CJ. 2003. The apoptosis-necrosis continuum: Insights from genetically modified mice. Veterinary Pathology 40 (5):481-95.
Shim EH, Johnson L, Noh HL, Kim YJ, Sun H, Zeiss C, Zhang H. 2003. Expression of the F-Box Protein SKP2 Induces Hyperplasia, Dysplasia, and Low-Grade Carcinoma in the Mouse Prostate. Cancer Res. 63(7):1583-8.
Hallaq H, Pinter E, Enciso J, McGrath J, Zeiss C, Brueckner M, Madri J, Jacobs HC, Wilson CM, Vasavada H, Jiang X, Bogue CW. 2004. A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels. Development. 131(20):5197-209.
Zeiss CJ, Neal J and Johnson EA. 2004. Caspase-3 in neonatal retinal development and degeneration. Invest Ophthalmol Vis Sci. 45(3):964-70.
Zeiss CJ and Johnson EA. 2004. Proliferation of microglia, but not photoreceptors in rd-1. Invest Ophthalmol Vis Sci. 45(3):971-6.
Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, Sangiovanni JP, Mane SM, Mayne ST, Bracken MB, Ferris FL, Ott J, Barnstable C, Hoh J. 2005. Complement Factor H Polymorphism in Age-Related Macular Degeneration. Science. Apr 15;308(5720):385-9.
Zeiss C, Allore HG, Towle V, Tao W. 2005. CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina. In press, Experimental Eye Research.
Zeiss CJ. 2005. The murine dopaminergic system: functional neuroanatomy and a review of genetically altered mice. In press, Veterinary Pathology
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