Yale at ARVO 2005


1. (36/B10) Myocilin is Processed in the Secretory Pathway by an Endoproteolytic Cleavage at Arg226 (Sunday, May 1 8:30 AM - 10:15 AM)
J.Escribano1, D.Aroca-Aguilar1, F.Snchez-Snchez1, S.Ghosh2, M.Coca-Prados2. 1Genetics, Castilla La Mancha Medical School, Albacete, Spain; 2Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT.
Poster Session: 107. Genetics I
Glaucoma

2. (184/B158) ARPE-19 Cells Are Protected Against Hydrogen Peroxide-Induced Cell Death by Multiple Growth Factors (Sunday, May 1 8:30 AM - 10:15 AM)
B.Chen1, C.J. Barnstable1, J.Tombran-Tink1,2. 1Ophthalmology & Visual Sci, Yale University-Sch of Med, New Haven, CT; 2Div Pharmaceutical Sciences, UMKC, Kansas City, MO.
Poster Session: 111. Neuroprotection
Retinal Cell Biology

3. (396/B370) Is Repeat Macular Laser Photocoagulation Effective in the Management of Diabetic Macular Edema? (Sunday, May 1 8:30 AM - 10:15 AM)
S.R. Vora1A, C.L. Hagedorn1A, N.Khan1A, M.Aslan1B, J.P. Concato1B, R.A. Adelman1A. ADepartment of Ophthalmology, BDepartment of Internal Medicine, 1Yale University School of Medicine, New Haven, CT.
Poster Session: 116. Diabetic Retinopathy I
Retina+

4. (584/B558) Developmental Defects in Nuc1 Retina Affect Normal Physiological Function (Sunday, May 1 8:30 AM - 10:15 AM)
S.L. Hose1, C.Zhang1, C.Barnstable2, B.Lei3, P.L. Gehlbach1, M.F. Goldberg1, J.S. Zigler, Jr4, D.Sinha1. 1Ophthalmology, Johns Hopkins Univ Sch Med, Baltimore, MD; 2Ophthalmology and Neurobiology, Yale University School of Medicine, New Haven, CT; 3Ophthalmology, Veterinary Medicine and Surgery, University of Missouri-Columbia, Columbia, MO; 4National Eye Institute, National Institutes of Health, Bethesda, MD.
Poster Session: 122. Retinal Development
Retinal Cell Biology

5. (115/B89) Predictive Factors for Response to Selective Laser Trabeculoplasty in Glaucoma Patients on Maximal Medical Therapy (Sunday, May 1 2:30 PM - 4:15 PM)
B.A. Ford1, S.A. Cheema1, G.Shafranov1, M.B. Shields1, M.Wand2. 1Ophthalmology, Yale University, New Haven, CT; 2Ophthalmology, University of Connecticut, Farmington, CT.
Poster Session: 110. Clinical Research I
Glaucoma

6. (1086) Applications of Nanotechnology to Tissue Engineering (Monday, May 2 8:57 AM - 9:10 AM)
E.B. Lavik. Biomedical Engineering, Yale University, New Haven, CT.
Paper Session: 210. Nanotechnology Applied to Ophthalmology- Special Topic Session
Retinal Cell Biology/Glaucoma, Retina+

7. (1656/B425) Space Shuttle Flight Microgravity Environment Induces Loss of Photoreceptor Outer Segments and other Pathomorphological Changes in the Retina (Monday, May 2 8:30 AM - 10:15 AM)
J.Tombran-Tink1, C.J. Barnstable2. 1School of Pharmacy, UMKC, Kansas City, MO; 2Dept. of Ophthalmology, Yale School of Medicine, New Haven, CT.
Poster Session: 245. Retinal Degeneration: Basic Mechanisms I
Retinal Cell Biology

8. (1657/B426) Hypergravity Induces Rod Photoreceptor Damage in Rats (Monday, May 2 8:30 AM - 10:15 AM)
C.J. Barnstable1, A.J. Barnstable1, A.R. Tink2, S.Viviano1, L.Baer3, C.Wade3, J.Tombran-Tink2. 1Ophthalmology & Visual Science, Yale University School Of Med, New Haven, CT; 2Pharmaceutical Sciences, UMKC, Kansas City, MO; 3Ames Research Center, Moffett Field, CA.
Poster Session: 245. Retinal Degeneration: Basic Mechanisms I
Retinal Cell Biology

9. (1955/B724) Impact of New Written Informed Consent Guidelines on Residency Participation in Ophthalmic Surgery (Monday, May 2 8:30 AM - 10:15 AM)
S.J. Lee, R.A. Adelman. Ophthalmology, Yale University, New Haven, CT.
Poster Session: 257. Eye Health Care Delivery, Utilization and Cost
Clinical & Epidemiologic Research/Lens

10. (1294/B63) A Pedf Peptide Encapsulated in Controlled Release Poly (Lactic-Co-Glycolic Acid) Microspheres Protects Retinal Ganglion Cells From Transient Ischemic Injury (Monday, May 2 11:15 AM - 1:00 PM)
H.Li1A, V.V. Tran1B, Y.Y. Hu1B, W.M. Saltzman1B, C.J. Barnstable1A, J.Tombran-Tink1A,2. AOphthalmology/Visual Science, BBiomedical Engineering, 1Yale Univ School of Medicine, New Haven, CT; 2Pharmaceutical Sciences, UMKC, Kansas City, MO.
Poster Session: 235. Neuroprotection, Neuro-regeneration and Blood Flow I
Glaucoma

11. (1401/B170) Significance of Fluorescein Angiogram Retinal Filling Time in Age-Related Macular Degeneration (Monday, May 2 11:15 AM - 1:00 PM)
C.L. Hagedorn1, T.L. Lucas2, R.A. Adelman1. 1Ophthalmology, Yale University, New Haven, CT; 2College of Medicine, Medical University of South Carolina, Charleston, SC.
Poster Session: 239. ARMD II and Angiogenesis I
Retina+/Retinal Cell Biology

12. (1420/B189) Angiostatin Inhibits Pathologic Neovascularization in a Mouse Model of Ischemic Retinopathy (Monday, May 2 11:15 AM - 1:00 PM)
R.A. Adelman1, F.Lu1,2, J.Zhang2, M.Yan2. 1Ophthalmology and Visual Science, Yale Eye Center, Yale University School of Medicine, New Haven, CT; 2Ophthalmology, West China Hospital, Sichuan University, China.
Poster Session: 239. ARMD II and Angiogenesis I
Retina+/Retinal Cell Biology

13. (1748/B517) Components of the Retinoid Cycle and Retinoid Analysis in the Bovine Ciliary Epithelium (Monday, May 2 11:15 AM - 1:00 PM)
M.Salvador-Silva1, S.Ghosh1, G.G. Garwin2, J.C. Saari2, M.Coca-Prados1. 1Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT; 2Ophthalmology, University of Washington, Seattle, WA.
Poster Session: 249. Visual Retinoid Cycle
Biochemistry & Molecular Biology

14. (2230/B999) Light Deprivation Retarded the Maturation of Retinal Ganglion Cell Dendritic Stratification (Monday, May 2 3:00 PM - 4:45 PM)
H.-P.Xu, N.Tian. Ophthalmology & Visual Science, Yale Univ School of Medicine, New Haven, CT.
Poster Session: 269. Retinal Ganglion Cell Circuitry and Signaling
Visual Neurophysiology

15. (3092/B645) STAT3 Protects Ganglion Cells in Ischemic Mouse Retina (Tuesday, May 3 8:30 AM - 10:15 AM)
C.Zhang1,2A, H.Li2B, M.G. Liu2B, C.J. Barnstable2B, X.Y. Fu2A, S.S. M. Zhang2B,2A. 1Peking University Eye Center, Third Hospital of Peking University, Beijing, China; ADepartment of Pathology, BDepartment of Ophthalmology, 2Yale School of Medicine, New Haven, CT.
Poster Session: 364. Retina/RPE: Gene Regulation/Transcription
Biochemistry & Molecular Biology

16. (3106/B659) PEDF and the SERPINS: Phylogeny, Sequence Conservation, and Functional Domains (Tuesday, May 3 8:30 AM - 10:15 AM)
X.Xu1, S.Aparicio2, A.R. Tink2, N.Lara2, S.Sawant2, S.S. M. Zhang1, C.J. Barnstable1, J.Tombran-Tink1,2. 1Ophthalmology and Visual Science, Yale Univeristy School of Medicine, New Haven, CT; 2Div Pharmaceutical Sciences, University of Missouri-Kansas City, Kansas City, MO.
Poster Session: 364. Retina/RPE: Gene Regulation/Transcription
Biochemistry & Molecular Biology

17. (3107/B660) PEDF Regulates a Group of Six Interferon-Inducible Genes That Are Highly Expressed in Actively Dividing RPE Cells via the p38MAP Kinase Pathway (Tuesday, May 3 8:30 AM - 10:15 AM)
S.E. Aparicio1, M.Liu2, S.Sawant1, N.Lara1, S.-M.Zhang2, C.J. Barnstable2, J.Tombran-Tink1,2. 1Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, MO; 2Dept. of Ophthalmology, Yale School of Medicine, New Haven, CT.
Poster Session: 364. Retina/RPE: Gene Regulation/Transcription
Biochemistry & Molecular Biology

18. (3108/B661) PEDF Inhibits VEGF-Induced Cytoprotection of Endothelial Cell via Inhibition of VEGF-R2/KDR Phosphorylation (Tuesday, May 3 8:30 AM - 10:15 AM)
L.Chen1, S.S. M. Zhang1, J.Tombran-Tink1,2, C.J. Barnstable1. 1Ophthalmology/Visual Science, Yale Univ Med Sch, New Haven, CT; 2Div Pharmaceutical Sciences, UMKC, Kansas City, MO.
Poster Session: 364. Retina/RPE: Gene Regulation/Transcription
Biochemistry & Molecular Biology

19. (3153/B706) Distinct Functions of STAT and MAPK Signals in Müller Glia Development (Tuesday, May 3 8:30 AM - 10:15 AM)
S.S. M. Zhang1,2, M.-G.Liu1, L.Chen1, C.J. Barnstable1. 1Dept Ophthalmology and Visual Science, Yale School Medicine, New Haven, CT; 2Pathology, Yale School of medicine, New Haven, CT.
Poster Session: 365. Development: Gene and Protein Expression
Biochemistry & Molecular Biology

20. (3154/B707) Protein Kinase C Regulates Rod Photoreceptor Differentiation Through Modulating STAT3 Signaling (Tuesday, May 3 8:30 AM - 10:15 AM)
M.-G.Liu1A, C.J. Barnstable1A, X.-Y.Fu1B, S.S. M. Zhang1A,1B. AOphthalmology and Visual Science, BPathology, 1Yale University School of Medicine, New Haven, CT.
Poster Session: 365. Development: Gene and Protein Expression
Biochemistry & Molecular Biology

21. (3155/B708) Regulation of Factors Controlling the Onset of Neovascularization in the Vldlr Mutant Mouse (Tuesday, May 3 8:30 AM - 10:15 AM)
N.Lara1, S.E. Aparicio1, S.Sawant1, C.J. Barnstable2, B.Chang3, J.Tombran-Tink1,2. 1Pharmaceutical Sciences, Univ of Missouri Kansas City, Kansas City, MO; 2School of Medicine, Yale University, New Haven, CT; 3The Jackson Laboratory, Bar Harbor, ME.
Poster Session: 365. Development: Gene and Protein Expression
Biochemistry & Molecular Biology

22. (3156/B709) Inverse Trends in Expression of Promoters and Inhibitors of Angiogenesis at E15, PN5, and PN7 During Normal Retinal Development (Tuesday, May 3 8:30 AM - 10:15 AM)
S.S. Sawant1, N.Lara1, S.Aparicio1, C.J. Barnstable2, J.Tombran-Tink1. 1Pharmaceutical Science, U.M.K.C., Kansas City, MO; 2Ophthalmology, Yale School of Medicine, New Haven, CT.
Poster Session; 365. Development: Gene and Protein Expression
Biochemistry & Molecular Biology

23. (3034/B587) Growth Conditions Affect the Formation of Tight Junctions in ARPE-19 Cells (Tuesday, May 3 11:15 AM - 1:00 PM)
Y.Luo, M.Fukuhara, Y.Zhou, C.Rahner, L.Rizzolo. Surgery/Ophthalmology, Yale University, New Haven, CT.
Poster Session: 362. RPE: Cell Culture and Physiology
Retinal Cell Biology/Retina+

24. (3194/B747) Acquired Lenticular Metaplasia of Müller Cells in the Damaged Avian Retina (Tuesday, May 3 11:15 AM - 1:00 PM)
R.R. Dubielzig1, C.J. Zeiss2. 1Pathobiological Sciences, University of Wisconsin, Madison, WI; 2Section of Comparative Medicine, Yale Medical School, New Haven, CT.
Poster Session: 366. Animal Models of Ocular Disease I
Biochemistry & Molecular Biology/Anatomy & Pathology

25. (3227/B780) Enhanced Survival and Differentiation Into Photoreceptor in Retinal Progenitor Cells Transplantation Using Polymer Composite Graft (Tuesday, May 3 11:15 AM - 1:00 PM)
M.Tomita1, E.Lavik2, H.Klassen3, T.Zahir1, R.Langer4, M.J. Young1. 1Department of Ophthalmology, The Schepens Eye Research Institute, Harvard Medical School, Boston, MA; 2Yale University, New Haven, CT; 3Children's Hospital of Orange County and U.C. Irvine, Orange, CA; 4Massachusetts Institute of Technology, Cambridge, MA.
Poster Session: 368. Stem Cells II
Retinal Cell Biology

26. (2413) Somatostatin Mediates Na+/H+-Exchanger NHE1 Activity in the Ocular Ciliary Epithelium via the Nitric Oxide (NO)/cGMP Pathway (Tuesday, May 3 3:30 PM - 3:45 PM)
M.Coca-Prados1A, L.Choritz1A, M.Salvador-Silva1A, J.Geibel1B, S.Ghosh1A. AOphthalmology & Visual Sci, BSurgery, and Cellular and Molecular Physiology, 1Yale University Med School, New Haven, CT.
Paper Session: 331. Aqueous Humor Dynamics I
Physiology & Pharmacology

27. (3026/B579) Icon-Targeted Photodynamic Therapy for Treatment of Choroidal Neovascularization in a Laser-Induced Rat Model (Tuesday, May 3 3:00 PM - 4:45 PM)
F.Lu1,2, Z.Hu3, A.Garen3, R.A. Adelman1. 1Ophthal & Visual Sci, Yale Eye Center, Yale University School of Medicine, New Haven, CT; 2Ophthalmology, West China Hospital, Sichuan University, Chengdu, China; 3Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT.
Poster Session: 361. Age-related Macular Degeneration: Basic Mechanisms III
Retinal Cell Biology

29. (4056/B414) Fluorescein Angiography as an Indicator of Stroke Risk: Correlation of Arm-Retina Time and Carotid Artery Stenosis (Wednesday, May 4 8:30 AM - 10:15 AM)
A.P. Swan1, C.L. Hagedorn1, T.L. Lucas2, R.A. Adelman1. 1Ophthalmology, Yale School of Medicine, New Haven, CT; 2Ophthalmology, Medical University of South Carolina, Charleston, SC.
Poster Session: 445. Retinal Vascular Disease, CSC, Other Acquired Maculopathies
Retina+/Clinical & Epidemiologic Research, Cornea, Visual Psychophysics/Physiological Optics

30. Organizer (Wednesday, May 4 1:15 PM - 2:45 PM)
M.Salvador-Silva. Ophthalmology, Yale University, New Haven, CT.
Workshop: 465. Pizza with a Prof: Ask the Experts

31. Moderator (Wednesday, May 4 1:15 PM - 2:45 PM)
C.J. Barnstable. Ophthalmology & Visual Science, Yale University School Of Med, New Haven, CT.
Special Interest Group (SIG): 471. Targeting Degeneration and Neovascularization with PEDF: Emerging Opportunities for Ocular Diseases - SIG
Retinal Cell Biology

32. Expression and Regulation of PEDF in the Eye (Wednesday, May 4 1:15 PM - 2:45 PM)
C.J. Barnstable. Ophthalmology & Visual Science, Yale University School Of Med, New Haven, CT.
Special Interest Group (SIG): 471. Targeting Degeneration and Neovascularization with PEDF: Emerging Opportunities for Ocular Diseases - SIG
Retinal Cell Biology

33. Organizer (Wednesday, May 4 1:15 PM - 2:45 PM)
C.Barnstable. Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT.
Special Interest Group (SIG): 471. Targeting Degeneration and Neovascularization with PEDF: Emerging Opportunities for Ocular Diseases - SIG
Retinal Cell Biology

34. (3902/B260) Oculix Laser Doppler Flowmetry and Near Infra-Red Spectroscopy Study of Autonomic Nervous System Function in Response to Phenylephrine Infusion (Wednesday, May 4 3:00 PM - 4:45 PM)
V.A. Diaz1A, K.I. Suh2, R.Adelman1A, D.G. Silverman1B, R.R. Ansari2. AOphthalmology and Visual Science, BAnesthesiology, 1Yale Univ Sch of Med, New Haven, CT; 2NASA Glenn Research Center, Cleveland, OH.
Poster Session: 440. Blood Flow I
Physiology & Pharmacology/Anatomy & Pathology, Retina+

35. (4484/B842) MT1-MMP Expression and Promoter Activity in Transgenic Mouse Cornea (Wednesday, May 4 3:00 PM - 4:45 PM)
J.-H.Chang, J.A. D. Javier, F.H. Casanova, D.T. Azar. Ophthalmology, Massachusetts Eye and Ear Infirmary/Schepens Eye Research Institute, Boston, MA.
Poster Session: 457. Corneal Neovascularization
Cornea/Retina+

36. (5035/B238) Paintball Related Ocular Trauma (Thursday, May 5 8:30 AM - 10:15 AM)
P.J. Pahk, R.A. Adelman. Ophthalmology, Yale University, New Haven, CT.
Poster Session: 534. Cornea, Anterior Segment, Uveitis and Ocular Trauma
Clinical & Epidemiologic Research

37. (5475/B678) Anatomical and Functional Outcome With Various Surgical Techniques in the Management of Pseudophakic Retinal Detachments (Thursday, May 5 10:45 AM - 12:30 PM)
A.V. Arya1, V.Y. Njike2, C.L. Hagedorn1, M.Engelbert3, R.Adelman1. 1Ophthalmology, Yale Eye Center, New Haven, CT; 2Preventive Medicine, Yale-Griffin Prevention Research Center, Derby, CT; 3Internal Medicine, Griffin Hospital, Derby, CT.
Poster Session: 551. Advances in Vitreoretinal Surgery II
Retina+/Lens, Retinal Cell Biology

38. (5570/B773) A Study of Postoperative Endophthalmitis in Halifax, Canada (Thursday, May 5 10:45 AM - 12:30 PM)
M.W. Dorey1, B.A. Ford2, S.P. George1. 1Ophthalmology, Dalhousie University, Halifax, NS, Canada; 2Ophthalmology, Yale University, New Haven, CT.
Poster Session: 552. Advances in Vitreoretinal Surgery III: Retinal Detachment and Endophthalmitis
Retina+/Physiology & Pharmacology, Retinal Cell Biology, Visual Psychophysics/Physiological Optics

39. PEDF: Past, Present and Future (Wednesday, May 4 1:15 PM - 2:45 PM)
J.Tombran-Tink. Pharmaceutical Sciences, Univ of MO - Kansas City.
Special Interest Group (SIG): 471. Targeting Degeneration and Neovascularization with PEDF: Emerging Opportunities for Ocular Diseases - SIG
Retinal Cell Biology

40. Moderator (Wednesday, May 4 1:15 PM - 2:45 PM)
J.Tombran-Tink. Pharmaceutical Sciences, Univ of MO - Kansas City, Kansas City, MO.
Special Interest Group (SIG): 471. Targeting Degeneration and Neovascularization with PEDF: Emerging Opportunities for Ocular Diseases - SIG
Retinal Cell Biology